Malformations of cortical development

Malformations due to abnormal neuronal and glial proliferation or apoptosis

Decreased proliferation/increased apoptosis: microcephalies

Increased proliferation/decreased apoptosis: megalencephalies

Abnormal proliferation (abnormal cell types):

Non-neoplastic (tuberous sclerosis, cortical dysplasia with balloon cells, hemimegalencephaly)
Neoplastic (association with disordered cortex): DNET, ganglioglioma, gangliocytoma

Malformations due to abnormal neuronal migration

Lissencephaly/subcortical band heterotopia spectrum

Cobblestone complex

Heterotopia (subependymal, subcortical, marginal glioneuronal)

Malformations due to abnormal cortical organisation

Polymicrogyria and schizencephaly

Cortical dysplasia without balloon cells

Microdysgenesis

Malformations of cortical development, not otherwise classified

DNET: dysembryoplastic neuroepithelioma.

Modified from: Barkovich AJ, Kuzniecky RI, Jackson GD, et al. Classification system for malformations of cortical development. Neurology 2001; 57:2168.

Graphic 62398 Version 4.0

خرید پکیج

Malformations of cortical development