Malformations due to abnormal neuronal and glial proliferation or apoptosis |
Decreased proliferation/increased apoptosis: microcephalies |
Increased proliferation/decreased apoptosis: megalencephalies |
Abnormal proliferation (abnormal cell types): - Non-neoplastic (tuberous sclerosis, cortical dysplasia with balloon cells, hemimegalencephaly)
- Neoplastic (association with disordered cortex): DNET, ganglioglioma, gangliocytoma
|
Malformations due to abnormal neuronal migration |
Lissencephaly/subcortical band heterotopia spectrum |
Cobblestone complex |
Heterotopia (subependymal, subcortical, marginal glioneuronal) |
Malformations due to abnormal cortical organisation |
Polymicrogyria and schizencephaly |
Cortical dysplasia without balloon cells |
Microdysgenesis |
Malformations of cortical development, not otherwise classified |