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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Treatment of children with precocious puberty

Treatment of children with precocious puberty
Schematic depiction of the pathways leading to precious puberty and the mechanisms of action for several drugs used for treatment. Central precocious puberty is also known as gonadotropin-dependent precocious puberty. For peripheral precocity (also known as gonadotropin-independent precocious puberty), the pathway for boys is shown on the left, and girls on the right.
GnRH: gonadotropin-releasing hormone; GnRHa: gonadotropin-releasing hormone analogue (eg, leuprolide, histrelin); LH: luteinizing hormone; FSH: follicle-stimulating hormone; AR: androgen receptor; ER: estrogen receptor.
* Preliminary data have been reported; treatment is still experimental.
References:
  1. Reiter EO, Mauras N, McCormick K, et al. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). J Pediatr Endocrinol Metab 2010; 23:999.
  2. Lenz AM, Shulman D, Eugster EA, et al. Bicalutamide and third-generation aromatase inhibitors in testotoxicosis. Pediatrics 2012; 126:e728.
  3. Leschek EW, Jones J, Barnes KM, et al. Six-year results of spironolactone and testolactone treatment of familial male-limited precocious puberty with addition of deslorelin after central puberty onset. J Clin Endocrinol Metab 1999; 84:175.
  4. Leschek EW, Flor AC, Bryant JC, et al. Effect of antiandrogen, aromatase inhibitor, and gonadotropin-releasing hormone analog on adult height in familial male precocious puberty. J Pediatr 2017; 190:229.
  5. Feuillan PP, Jones J, Cutler GB, et al. Letrozole treatment of precocious puberty in girls with the McCune Albright syndrome: A pilot study. J Clin Endocrinol Metab 2007; 92:2100.
  6. Feuillan PP, Jones J, Cutler GB Jr. Long-term testolactone therapy for precocious puberty in girls with the McCune-Albright syndrome. J Clin Endocrinol Metab 1993; 77:647.
  7. Eugster EA, Rubin SD, Reiter EO, et al. Tamoxifen treatment for precocious puberty in McCune-Albright syndrome: a multicenter trial. J Pediatr 2003; 143:60.
  8. Sims EK, Garnett S, Guzman F, et al. Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. Int J Pediatr Endocrinol 2012; 2012:26.
Fuqua JS. Treatment and outcomes of precocious puberty: An update. J Clin Endocrinol Metab 2013; 98:2198.
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