Schematic depiction of the pathways leading to precious puberty and the mechanisms of action for several drugs used for treatment. Central precocious puberty is also known as gonadotropin-dependent precocious puberty. For peripheral precocity (also known as gonadotropin-independent precocious puberty), the pathway for boys is shown on the left, and girls on the right.
GnRH: gonadotropin-releasing hormone; GnRHa: gonadotropin-releasing hormone analogue (eg, leuprolide, histrelin); LH: luteinizing hormone; FSH: follicle-stimulating hormone; AR: androgen receptor; ER: estrogen receptor. * Preliminary data have been reported; treatment is still experimental.
References:
Reiter EO, Mauras N, McCormick K, et al. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). J Pediatr Endocrinol Metab 2010; 23:999.
Lenz AM, Shulman D, Eugster EA, et al. Bicalutamide and third-generation aromatase inhibitors in testotoxicosis. Pediatrics 2012; 126:e728.
Leschek EW, Jones J, Barnes KM, et al. Six-year results of spironolactone and testolactone treatment of familial male-limited precocious puberty with addition of deslorelin after central puberty onset. J Clin Endocrinol Metab 1999; 84:175.
Leschek EW, Flor AC, Bryant JC, et al. Effect of antiandrogen, aromatase inhibitor, and gonadotropin-releasing hormone analog on adult height in familial male precocious puberty. J Pediatr 2017; 190:229.
Feuillan PP, Jones J, Cutler GB, et al. Letrozole treatment of precocious puberty in girls with the McCune Albright syndrome: A pilot study. J Clin Endocrinol Metab 2007; 92:2100.
Feuillan PP, Jones J, Cutler GB Jr. Long-term testolactone therapy for precocious puberty in girls with the McCune-Albright syndrome. J Clin Endocrinol Metab 1993; 77:647.
Eugster EA, Rubin SD, Reiter EO, et al. Tamoxifen treatment for precocious puberty in McCune-Albright syndrome: a multicenter trial. J Pediatr 2003; 143:60.
Sims EK, Garnett S, Guzman F, et al. Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. Int J Pediatr Endocrinol 2012; 2012:26.
Fuqua JS. Treatment and outcomes of precocious puberty: An update. J Clin Endocrinol Metab 2013; 98:2198.
Graphic 62460 Version 7.0
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟