Effect of octreotide on serum IGF-1

In this study of previously untreated acromegalic patients, 18 with macroadenomas and 6 with microadenomas, short-acting octreotide was administered for 24 weeks and then long-acting octreotide to 15 of the patients for another 24 weeks. Open circles represent the pre-treatment IGF-1 concentration, bull's eye marks the values at 24 weeks, and the closed circles the values at 48 weeks. N indicates normal age-related IGF-1 concentration at latest assessment.