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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Doxorubicin, cisplatin, and high-dose methotrexate (MAP) followed by surgery and MAP for nonmetastatic osteosarcoma (control arm, COG AOST 0331)

Doxorubicin, cisplatin, and high-dose methotrexate (MAP) followed by surgery and MAP for nonmetastatic osteosarcoma (control arm, COG AOST 0331)
Weeks Agents Dose Days
Induction MAP (weeks 1 through 10)
1, 6 Doxorubicin 37.5 mg/m2 per day by continuous IV infusion or IV push 1 and 2
Cisplatin 60 mg/m2 per day IV over four hours 1 and 2
4, 5, 9, 10 High-dose methotrexate 12 grams/m2 IV over four hours* 1
Leucovorin rescue 15 mg (approximately 10 mg/m2) every six hours IV or orally for 10 doses Starting 24 hours after beginning high-dose methotrexate
Surgery (week 11)
11 Resection or amputation
Postoperative MAP (weeks 12 through 29)
12, 17 DoxorubicinΔ 37.5 mg/m2 per day by continuous IV infusion or IV push 1 and 2
Cisplatin 60 mg/m2 per day IV over four hours 1 and 2
22, 26 DoxorubicinΔ 37.5 mg/m2 per day IV over 24 hours 1 and 2
15, 16, 20, 21, 24, 25, 28, 29 High-dose methotrexate 12 grams/m2 IV over four hours 1
Leucovorin rescue 15 mg (approximately 10 mg/m2) every six hours IV or orally for 10 doses Starting 24 hours after beginning high-dose methotrexate
IV: intravenous.
* Some pediatric oncologists limit the methotrexate dose to 20 grams total (Meyers, PA, et al. J Clin Oncol 2005; 23:2004).
¶ Leucovorin doses adjusted depending on blood methotrexate levels.
Δ Dexrazoxane can be given with doxorubicin, although osteosarcoma-specific data are not available.
Created with data from:
  1. National Cancer Institute Clinical Trials. Phase III randomized study of neoadjuvant induction therapy comprising doxorubicin, cisplatin, and high-dose methotrexate (MAP) followed by surgery and adjuvant maintenance therapy comprising map alone versus map and peg-interferon alfa-2b or MAP combined with ifosfamide and etoposide in patients with resectable high-grade osteosarcoma; available at: https://clinicaltrials.gov/ct2/show/NCT00134030?term=AOST+0331&rank=1, accessed February 26, 2016.
  2. Goorin AM, Schwartzentruber DJ, Devidas M, et al. Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 2003; 21:1574.
  3. Geller DS, Goorlick R. Osteosarcoma: a review of diagnosis, management, and treatment strategies. Clin Adv Hematol Oncol 2010; 8:705.
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