Major symptoms and signs of hypothyroidism

Mechanism	Symptoms	Signs
Slowing of metabolic processes	Fatigue and weakness Cold intolerance Dyspnea on exertion Weight gain Cognitive dysfunction Intellectual disability (infantile onset) Constipation Growth failure	Slow movement and slow speech Delayed relaxation of tendon reflexes Bradycardia Carotenemia
Accumulation of matrix substances	Dry skin Hoarseness Edema Carpal tunnel syndrome	Coarse skin Puffy facies and loss of eyebrows Periorbital edema Enlargement of the tongue
Other	Decreased hearing Myalgia and paresthesia Depression Menorrhagia Arthralgia Pubertal delay	Diastolic hypertension Pleural and pericardial effusions Ascites Galactorrhea

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