Circadian alterations in lung function (as assessed by peak expiratory flow rate or FEV1) in normal subjects and asthmatics. The nadir occurs at approximately 4 AM in both groups, but the amplitude of the peak-to-trough swings is much larger in asthma.
Adapted from Hetzel, MR, Clark, TJ, Thorax 1980; 35:732.
Graphic 62825 Version 1.0
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