Algorithm for evaluation of asymptomatic proteinuria in children

Refer to UpToDate topics on the evaluation of proteinuria in children for further details.

BUN: blood urea nitrogen; C3: complement component 3; C4: complement component 4.
* For children between 6 and 24 months, the threshold value is 0.5 mg protein to mg creatinine.
¶ Persistent proteinuria, elevated blood pressure, and impaired renal function (elevated serum creatinine) are suggestive of renal parenchymal damage. Such patients should be referred to a pediatric nephrologist (or a clinician with expertise in the care of children with renal disease).

Adapted with permission from: Hogg RJ, Portman RJ, Milliner D, et al. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE). Pediatrics 2000; 105:1242.

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Algorithm for evaluation of asymptomatic proteinuria in children