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Cooperative cardiovascular project risk model for intracranial hemorrhage with thrombolytic therapy

Cooperative cardiovascular project risk model for intracranial hemorrhage with thrombolytic therapy
Risk factors*
  • Age ≥75 years
  • Black race
  • Female sex
  • Prior history of stroke
  • Systolic blood pressure ≥160 mmHg
  • Weight ≤65 kg for females or ≤80 kg for males
  • INR >4 or PT >24
  • Use of alteplase (versus other thrombolytic agent)
Risk score Rate of intracranial hemorrhage (%)
0 or 1 0.69
2 1.02
3 1.63
4 2.49
≥5 4.11

INR: international normalized ratio; PT: prothrombin time.

* Each risk factor is worth 1 point if present, 0 points if absent. Points are added to determine the risk score.
Data from: Brass LM, Lichtman JH, Wang Y, et al. Intracranial hemorrhage associated with thrombolytic therapy for elderly patients with acute myocardial infarction: results from the cooperative cardiovascular project. Stroke 2000; 31:1802.
Graphic 62946 Version 7.0

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