Version May 2024
| Procedure | Potential organisms encountered | Routine prophylaxis recommended | First-choice antibiotic | Common antibiotic choices | Comments |
| Angiography, angioplasty, thrombolysis, arterial closure device placement, stent placement | Staphylococcus aureus, S. epidermidis | No | None | Cefazolin (2 g IV if <120 kg, 3 g IV if ≥120 kg IV) (if high-risk stent infection). If penicillin-allergic, can use vancomycin (15 mg/kg IV; max 2 g) or clindamycin (900 mg IV). | Procedure classification: clean |
| Endograft placement | S. aureus, S. epidermidis | Yes | Cefazolin (2 g IV if <120 kg, 3 g IV if ≥120 kg IV) | If penicillin-allergic, can use vancomycin or clindamycin | Procedure classification: clean |
| Superficial venous insufficiency treatment | S. aureus, S. epidermidis | No | None | None | Procedure classification: clean |
| IVC filter placement | S. aureus, S. epidermidis | No | None | None | Procedure classification: clean |
| Tunneled central venous access | S. aureus, S. epidermidis | No consensus | None | Cefazolin (2 g IV if <120 kg, 3 g IV if ≥120 kg IV) (eg, immunocompromised patients before chemotherapy; history of catheter infection). If penicillin-allergic, can use vancomycin (15 mg/kg IV; max 2 g) or clindamycin (900 mg IV). | Procedure classification: clean (nontunneled catheter: no prophylaxis) |
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