Version July 2025
| Drug | Formulations | Starting dose | Maintenance dose | Comments |
| Donepezil | Tablet or orally disintegrating tablet (ODT) | 5 mg orally once daily | 10 mg once daily (increased after 4 to 6 weeks)* | No dose adjustments for kidney or liver impairment. |
| Transdermal patch | One patch (5 mg/24 hours) transdermally once weekly | One patch (10 mg/24 hours) once weekly (increased after 4 to 6 weeks) | Can cause application site reactions; rotate site. Must be refrigerated. Allow to warm to room temperature prior to administration. Start with morning dosing to avoid sleep disturbances; may switch to nighttime dosing if daytime nausea occurs. No dose adjustments for kidney or liver impairment. | |
| Galantamine | Immediate-release tablet or solution | 4 mg orally twice daily | 12 mg twice daily (increased in monthly intervals by 4 mg twice-daily increments) | Give with meals. Maximum 8 mg twice daily with moderate kidney or liver impairment. Do not use with severe kidney or liver impairment. |
| Extended-release capsule | 8 mg orally once daily | 24 mg once daily (increased in monthly intervals by 8 mg once-daily increments) | Give with a meal. Maximum 16 mg once daily with moderate kidney or liver impairment. Do not use with severe kidney or liver impairment. | |
| Benzgalantamine | Delayed-release tablet | 5 mg orally twice daily | 15 mg twice daily (increased in monthly intervals by 5 mg twice-daily increments) | Maximum 10 mg twice daily with moderate kidney or liver impairment. Do not use with severe kidney or liver impairment. Do not split, crush, or chew. |
| Rivastigmine | Capsule | 1.5 mg orally twice daily | 6 mg twice daily (increased in 2- to 4-week intervals by 1.5 mg twice-daily increments) | Give with meals. Slow and cautious titration with kidney or liver impairment or low body weight. |
| Transdermal patch | One patch (4.6 mg/24 hours) transdermally once daily | One patch (9.5 to 13.3 mg/24 hours) once daily (increased in monthly intervals to 9.5 mg/24 hours, then 13.3 mg/24 hours) | Can cause rash; rotate sites. Fewer side effects than capsule. Maximum dose 4.6 mg/24 hours with mild to moderate liver impairment or low body weight. Do not use with severe liver impairment. |
