Histologic images of healed plaque rupture

(A) Cross-sectional histologic image of healed plaque rupture. (Movat, magnification x40). Necrotic core (NC) is covered by thick fibrous cap.
(B) Magnified image (x200) of the inset in panel A. Type III collagen is overlying the rupture site (yellow arrow).
(C) Sirius red staining corresponding to panel B under the polarized light, the NC is identified as a black area contained within the type III collagen layer (green under polarized light) of the fibrous cap.
(D) Healed plaque rupture with severe luminal narrowing (Movat, magnification x40).
(E, F) Sirius red stained sections corresponding to panel D under the normal (E) and polarized light (F), respectively.
(G, H, I) Magnified image (x200) of the insets in panel D. There are multiple layered NCs, which ruptured at various times prior to the eventual multi-layered appearance, which indicate that repeated episodes of plaque rupture had occurred.