Systolic BP ≥160 mmHg or diastolic BP ≥100 mmHg |
Diabetes mellitus |
Established CV disease including any history of: |
Ischemic stroke, cerebral hemorrhage, or transient ischemic attack |
Myocardial infarction, angina, coronary revascularization, or heart failure |
Peripheral artery disease |
Retinal hemorrhages or exudates and papilledema |
Established or subclinical renal disease including: |
Microalbuminuria or proteinuria (>30 mg/24 h) |
Serum creatinine in men >1.5 mg/dL, women >1.4 mg/dL |
Calculated or estimated glomerular filtration rate <60 mL/min/1.73 m2 |
Subclinical organ damage previously documented by: |
ECG or echocardiogram revealing left ventricular hypertrophy |
Carotid ultrasound study revealing wall thickening or plaque |
Three or more of the following CV risk factors: |
Age (men >55 y, women >65 y) |
Cigarette smoking |
Dyslipidemia as measured by: |
Total cholesterol >190 mg/dL or |
Low-density lipoprotein cholesterol >130 mg/dL or |
High-density lipoprotein cholesterol (men <40 mg/dL; women <46 mg/dL) or |
Triglyceride >150 mg/dL |
Fasting plasma glucose >100 mg/dL |
Family history of premature CV disease (first-degree male relative age <55 y or first-degree female relative <65 y) |
Abdominal obesity male waist circumference >40 in; female >35 in (in persons of East Asian ancestry: male waist circumference >35 in and for women >31 in) |
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