Version May 2024
| Indication or contraindication | Antihypertensive drugs |
| Compelling indications (major improvement in outcome independent of blood pressure) | |
| Heart failure with reduced ejection fraction | ACE inhibitor or ARB, beta blocker, diuretic, aldosterone antagonist* |
| Postmyocardial infarction | ACE inhibitor or ARB, beta blocker, aldosterone antagonist |
| Proteinuric chronic kidney disease | ACE inhibitor or ARB |
| Angina pectoris | Beta blocker, calcium channel blocker |
| Atrial fibrillation rate control | Beta blocker, nondihydropyridine calcium channel blocker |
| Atrial flutter rate control | Beta blocker, nondihydropyridine calcium channel blocker |
| Likely to have a favorable effect on symptoms in comorbid conditions | |
| Benign prostatic hyperplasia | Alpha blocker |
| Essential tremor | Beta blocker (noncardioselective) |
| Hyperthyroidism | Beta blocker |
| Migraine | Beta blocker, calcium channel blocker |
| Osteoporosis | Thiazide diuretic |
| Raynaud phenomenon | Dihydropyridine calcium channel blocker |
| Contraindications | |
| Angioedema | Do not use an ACE inhibitor |
| Bronchospastic disease | Do not use a non-selective beta blocker |
| Liver disease | Do not use methyldopa |
| Pregnancy (or at risk for) | Do not use an ACE inhibitor, ARB, or renin inhibitor (eg, aliskiren) |
| Second- or third-degree heart block | Do not use a beta blocker, nondihydropyridine calcium channel blocker unless a functioning ventricular pacemaker |
| Drug classes that may have adverse effects on comorbid conditions | |
| Depression | Generally avoid beta blocker, central alpha-2 agonist |
| Gout | Generally avoid loop or thiazide diuretic |
| Hyperkalemia | Generally avoid aldosterone antagonist, ACE inhibitor, ARB, renin inhibitor |
| Hyponatremia | Generally avoid thiazide diuretic |
ACE: angiotensin-converting enzyme; ARB: angiotensin receptor blocker.
* A benefit from an aldosterone antagonist has been demonstrated in patients with NYHA class III-IV heart failure or decreased left ventricular ejection fraction after a myocardial infarction.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
