Version June 2024
| Granulomatous diseases | Diagnostic tests |
| Infections | |
| Mycobacterial | |
| Tuberculosis (M. tuberculosis) | PPD, CXR, QFT-G, AFB smear and culture |
| Leprosy (M. leprae) | Skin smear or biopsy, PCR |
| Atypical mycobacterial (eg, M. chelonei) | AFB smear and culture |
| Treponemal | |
| Syphilis | RPR, FTA-ABS |
| Bacterial | |
| Rhinoscleroma (Klebsiella rhinoscleromatis) | Culture |
| Fungal | |
| Histoplasmosis (Histoplasma capsulatum) | Special stains, culture, serology |
| Protozoan | |
| Leishmaniasis (Leishmania braziliensis) | Skin smear or aspirate, PCR, biopsy showing intra and extracellular Leishman bodies |
| Rhinosporidiosis (Rhinosporidium seeberi) | Biopsy showing granulomas and typical sporangia |
| Vasculitides | |
| Granulomatosis with polyangiitis (Wegener's) | ANCA, biopsy |
| Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) | Peripheral eosinophilia, ANCA, biopsy |
| Malignancy | |
| Lethal midline granulomatosis (extranodal NK/T cell lymphoma) | Biopsy showing polymorphous lymphoid infiltrate; immunophenotype positive for CD2, surface CD3, CD56; clonal EBV genomes present |
| Nonkeratinizing nasopharyngeal carcinoma | Biopsy shows an epithelial neoplasm with a dense lymphoplasmacytic infiltrate (predominantly T cells); associated with EBV infection |
| Other | |
| Sarcoidosis | Biopsy showing noncaseating granulomas, CXR |
| Cocaine-induced midline destructive lesion | History of cocaine use |
| Granulomatous rosacea | Granulomatous perifolliculitis |
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