Version May 2024
| Features suggestive of multiple sclerosis |
| Relapses and remissions |
| Onset between ages 15 and 50 years |
| Optic neuritis |
| Lhermitte sign |
| Internuclear ophthalmoplegia |
| Fatigue |
| Heat sensitivity (Uhthoff phenomenon) |
| Features atypical for multiple sclerosis |
| Steady progression |
| Onset before age 10 or after age 50 years |
| Cortical deficits such as aphasia, apraxia, alexia, or neglect |
| Rigidity or sustained dystonia |
| Convulsions |
| Early dementia |
| Deficit developing within minutes |
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