American College of Rheumatology 20% improvement criteria (ACR20)^[1]

At least 20% improvement in:

1. Swollen joint count

2. Tender joint count

and 3 of the following 5 variables:

3. Patient-assessed global disease activity (eg, by VAS)

4. Evaluator-assessed global disease activity (eg, by VAS)

5. Patient pain assessment (eg, by VAS)

6. Functional disability (eg, by HAQ)

7. Acute phase response (ESR or CRP)

A 50 and 70% ACR response (ACR50 and ACR70, respectively) represents respective improvement of at least 50 or 70%.^[2]

VAS: visual analog scale; HAQ: Health Assessment Questionnaire; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; ACR: American College of Rheumatology.

References:

Felson DT, Anderson JJ, Boers M, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995; 38:727.
Felson DT, Anderson JJ, Lange ML, et al. Should improvement in rheumatoid arthritis clinical trials be defined as fifty percent or seventy percent improvement in core set measures, rather than twenty percent?. Arthritis Rheum 1998; 41:1564.

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خرید پکیج

American College of Rheumatology 20% improvement criteria (ACR20)[1]

American College of Rheumatology 20% improvement criteria (ACR20)^[1]