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Organization of the human T cell receptor-delta chain locus

Organization of the human T cell receptor-delta chain locus
There is 1 V delta gene within the V alpha region. There are also 5 genes in V alpha that may rearrange with either J alpha or J delta. There is an additional V delta gene between V alpha and D delta, and 1 more 3' (to the right) of C delta. There are 3 D delta, and 4 J delta genes. There is a single C delta gene.
V: variable; D: diversity; J: joining; C: constant; 3': three prime end of the DNA strand.
Adapted from: Moss PA, Rosenberg WM, Bell JL. The human T cell receptor in health and disease. Ann Rev Immunol 1992; 10:71.
Graphic 64384 Version 3.0

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