At 19 postmenstrual weeks, this fetus with trisomy 13 and alobar holoprosencephaly also displays abnormal facies

(A) The orbits are very close together (hypotelorism).
(B) There is disruption of the hard palate consistent with a midline cleft lip and palate (arrow).

Courtesy of Ana Monteagudo, MD.

Graphic 64494 Version 5.0

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