ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Irinotecan and oxaliplatin-based regimens for metastatic colorectal cancer

Irinotecan and oxaliplatin-based regimens for metastatic colorectal cancer
Regimen* Irinotecan Oxaliplatin Leucovorin Fluorouracil/capecitabine Schedule
FOLFIRI[1] 180 mg/m2 day 1   400 mg/m2 over two hours day 1 Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 to 3000 mg/m2Δ over 46 hours, continuous infusion Every two weeks
Douillard regimen[2] 180 mg/m2 day 1   200 mg/m2 leucovorin over two hours days 1 and 2 before fluorouracil Fluorouracil 400 mg/m2 bolus then 600 mg/m2 over 22 hours days 1 and 2 Every two weeks
FOLFOX 4[3]   85 mg/m2 day 1 400 mg/m2 over two hours days 1 and 2 before fluorouracil◊ Fluorouracil 400 mg/m2 bolus, then 600 mg/m2 over 22 hours days 1 and 2 Every two weeks
FOLFOX 6[1]   100 mg/m2 day 1 400 mg/m2 over two hours day 1 Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 to 3000 mg/m2Δ over 46 hours, continuous infusion Every two weeks
Modified FOLFOX 6[4,5]   85 mg/m2 day 1 350 mg total dose over two hours day 1 Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 mg/m2 over 46 hours Every two weeks
FOLFOX 7[6]   130 mg/m2 day 1 400 mg/m2 over two hours day 1 Fluorouracil 400 mg/m2 bolus, then 2400 mg/m2 over 46 hours Every two weeks
Modified FOLFOX 7[7] (Optimox)   100 mg/m2 day 1 400 mg/m2 over two hours day 1 Fluorouracil 3000 mg/m2 over 46 hours Every two weeks
Modified FOLFOX 7[8] (CONcePT)§   85 mg/m2 day 1 200 mg/m2 over two hours day 1 Fluorouracil 2400 mg/m2 over 46 hours Every two weeks
XELOX[5]   130 mg/m2 day 1   Capecitabine 1000 mg/m2 orally twice per day on days 1 to 14 Every three weeks
FOLFOXIRI[9] 165 mg/m2 day 1 85 mg/m2 day 1 400 mg/m2 leucovorin over two hours day 1 Fluorouracil 3200 mg/m2 over 48 hours Every two weeks
* All doses shown are for intravenous (IV) administration, except capecitabine.
¶ Leucovorin doses given for the d,l racemic mixture.
Δ 2400 mg/m2 dose is commonly used.
◊ The original trial report indicated a leucovorin dose of 200 mg/m2 daily, but this was an error, and the correct dose used in the protocol was 400 mg/m2 (R Goldberg, personal communication).
§ FOLFOX 7 was administered with bevacizumab (5 mg/kg every two weeks) in the CONCePT trial.
References:
  1. Tournigand C, André T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22:229.
  2. Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355:1041.
  3. Goldberg R, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22:23.
  4. Cheeseman SL, Joel SP, Chester JD, et al. A 'modified de Gramont' regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer. Br J Cancer 2002; 87:393.
  5. Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol 2008; 26:3523.
  6. Maindrault-Goebel F, de Gramont A, Louvet C, et al. High-dose intensity oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX 7). Eur J Cancer 2001; 37:1000.
  7. Chibaudel B, Maindrault-Goebel F, Lledo G, et al. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol 2009; 27:5727.
  8. Grothey A, Hart L, Rowland K, et al. Intermittent oxaliplatin administration improves time to-treatment failure in metastatic colorectal cancer: final results of the Phase III of the CONcePT Trial. J Clin Oncol 2008; 26(Suppl):Abstract 4010.
  9. Falcone A, Ricci S, Brunetti I, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 2007; 25:1670.
Graphic 64504 Version 14.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟