| Leaflet |
| Degenerative valve disease (mitral valve prolapse) |
| Rheumatic fever |
| Infective endocarditis (acute and chronic) |
| Systemic inflammatory disorders |
| Systemic lupus erythematosus |
| Scleroderma |
| Connective tissue disorders |
| Marfan syndrome |
| Ehlers-Danlos syndromes |
| Pseudoxanthoma elasticum |
| Congenital |
| Mitral valve clefts |
| Parachute mitral valve |
| Endocardial cushion defects |
| Hypertrophic cardiomyopathy (systolic anterior movement of mitral valve) |
| Drug-related |
| Chordae tendineae |
| Myxomatous valve disease (mitral valve prolapse) |
| Infective endocarditis (acute and chronic) |
| Rheumatic fever |
| Spontaneous rupture |
| Myocardial infarction |
| Trauma |
