Osmotic regulation of ADH release and thirst

Relation between plasma ADH concentration and plasma osmolality in normal humans in whom the plasma osmolality was changed by varying the state of hydration. The osmotic threshold for thirst is a few mosmol/kg higher than that for ADH.

ADH: antidiuretic hormone.

Data from Robertson GL, Aycinena P, Zerbe RL. Neurogenic disorders of osmoregulation. Am J Med 1982; 72:339.