Comparison of sensitivity and specificity for rectal suction biopsy, contrast enema, and anorectal manometry in the diagnosis of Hirschsprung disease in children*

Test	Sensitivity	Specificity
Rectal suction biopsy	93%	100%
Rectal suction biopsy	(95% CI, 77-98 percent)	(95% CI, 96-100 percent)
Contrast enema	76%	97%
Contrast enema	(95% CI, 57-89 percent)	(95% CI, 91-99 percent)
Anorectal manometry	83%	93%
Anorectal manometry	(95% CI, 63-93 percent)	(95% CI, 85-97 percent)

* Diagnosis was confirmed by full-thickness rectal biopsy and exluded by clinical follow-up for at least 6 months.

Data from: De Lorijn, F, Reitsma, JB, Voskuijl, WP, et al. Diagnosis of Hirschsprung's disease: a prospective, comparative accuracy study of common tests. J Pediatr 2005; 146:787.

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