Version July 2025
| Drug | Scedosporium apiospermum | Lomentospora prolificans |
| Amphotericin B | – | IR[1] |
| Voriconazole | + | – |
| Posaconazole | + | – |
| Isavuconazole | + | – |
| Terbinafine | – | –* |
| Echinocandins | – | – |
| Olorofim (formerly F901318) | + | + |
| Fosmanogepix or APX001 (formerly E1211) | + | + |
IR: Intrinsic resistance.
* Terbinafine is sometimes used in combination with other antifungal agents for the treatment of L. prolificans infections for possible synergistic effect.