Cytomegalovirus pneumonitis

(A, B) High-resolution computed tomography images (1.0 mm collimation) at the levels of the azygos arch (A) and bronchus intermedius (B) show bilateral ground-glass opacities and poorly defined small nodules (arrows). A small right pleural effusion is also present.
(C) Photomicrograph of a biopsy specimen shows a moderate degree of interstitial fibrosis and chronic inflammation (thick arrow) as well as plugs of fibroblastic tissue in the lumens of several airspaces (thin arrows).
(D) Highly magnified photomicrograph shows several large cells containing intranuclear inclusions consistent with cytomegalovirus (thin arrows). (Compare size with hyperplastic type 2 pneumocytes [thick arrow].) The patient was a 28-year-old man with acute myelogenous leukemia.