Effectiveness of selected antiemetic agents for postoperative nausea and vomiting*

Drug	Relative risk (95% CI)
Drug	Nausea	Vomiting	Nausea and vomiting	Rescue antiemetic
Droperidol	0.65 (0.60-0.71)	0.65 (0.61-0.70)	0.62 (0.58-0.67)	0.53 (0.47-0.60)
Dexamethasone	0.57 (0.48-0.69)	0.51 (0.46-0.57)	0.49 (0.44-0.54)	0.50 (0.42-0.59)
Cyclizine	0.65 (0.47-0.90)	0.57 (0.43-0.75)	0.68 (0.58-0.80)	0.27 (0.14-0.62)
Metoclopramide	0.82 (0.76-0.88)	0.75 (0.70-0.81)	0.76 (0.70-0.82)	0.78 (0.69-0.88)
Ondansetron	0.68 (0.63-0.74)	0.55 (0.50-0.59)	0.56 (0.50-0.63)	0.55 (0.49-0.61)
Dolasetron	0.82 (0.76-0.90)	0.63 (0.51-0.76)	0.72 (0.62-0.83)	0.67 (0.57-0.79)
Tropisetron	0.77 (0.71-0.84)	0.59 (0.50-0.69)	0.70 (0.61-0.81)	0.62 (0.53-0.72)
Granisetron	0.53 (0.45-0.63)	0.40 (0.35-0.46)	0.39 (0.31-0.48)	0.29 (0.22-0.39)
Romasetron	0.62 (0.40-0.96)	0.42 (0.28-0.63)	0.51 (0.39-0.68)	0.38 (0.15-0.99)

Most commonly used antiemetics reduce the incidence of postoperative nausea and vomiting by approximately 25%. For further information refer to UpToDate content on postoperative nausea and vomiting.

* Placebo versus drug.

Data from: Carlisle J, Stevenson CA. Drugs for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2006; 3:CD004125.

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خرید پکیج

Effectiveness of selected antiemetic agents for postoperative nausea and vomiting*