Fibroblast response |
Mediators |
Increased fibroblast chemotaxis |
TGF-beta, IL-4, TNF-alpha and beta, PDGF, IFN gamma, ET-1 |
Increased fibroblast proliferation |
IL-1 alpha and beta, bFGF, aFGF, PDGF, IL-6, EGF, TGF-beta (via PDGF), ET-1, IL-17 |
Increased collagen synthesis |
TGF-β, IL-1 alpha and beta, IL-4, IGF |
Decreased collagen synthesis |
bFGF, IFN gamma and alpha, relaxin, EGF, TNF-alpha |
Increased collagenase synthesis |
IL-1 alpha and beta, bFGF, TNF-alpha and beta |
Decreased collagen synthesis |
TGF-beta |
Increased TIMP synthesis |
IL-1 alpha and beta, TGF-beta |
Decreased TIMP synthesis |
IL-6 |