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Cerebrospinal fluid patterns in different causes of viral meningitis in children

Cerebrospinal fluid patterns in different causes of viral meningitis in children
Virus WBC*
(cells/mm3)
RBC Glucose
(mg/dL)
Protein
(mg/dL)
Enterovirus 0 to 1000 None NL/SL <160
Parechovirus NL/SL None NL/SL NL
Herpes simplex virus ~100 None or NL/SL ~100 or higher
Epstein-Barr virus None NL
Cytomegalovirus None
Lymphocytic choriomeningitis virus None NL/SL NL/SL
Influenza NL/SL None NL NL/SL
Arboviruses   None NL  
Eastern equine encephalitis 400 to 4000
Western equine encephalitis ≤2000
West Nile virus <200 Up to 900
St. Louis encephalitis virus <200 ~200
CSF: cerebrospinal fluid; WBC: white blood cell; RBC: red blood cell; : elevated; : decreased; NL: normal; SL: slightly.
* In most cases of viral meningitis, the CSF WBC is within the range of 10 to 500 cells/microL, though higher values can be seen with some viruses. Normal CSF WBC counts can be seen in enteroviral meningitis, particularly in young infants. Normal CSF WBC can also rarely be seen in herpes simplex virus meningoencephalitis early in the course of infection. In most cases of viral meningitis, there is a mononuclear-predominant pleocytosis, although a neutrophil predominance has been described early in the course of enteroviral meningitis (ie, within the first 24 to 48 hours). For additional details, refer to UpToDate content on CSF interpretation in children with viral meningitis.
Data from:
  1. Feigin RD, Shackelford PG. Value of repeat lumbar puncture in the differential diagnosis of meningitis. N Engl J Med 1973; 289:571.
  2. Negrini B, Kelleher KJ, Wald ER. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 2000; 105:316.
  3. Rotbart HA. Viral meningitis. Semin Neurol 2000; 20:277.
  4. Sawyer MH. Enterovirus infections: diagnosis and treatment. Pediatr Infect Dis J 1999; 18:1033.
  5. Simko JP, Caliendo AM, Hogle K, Versalovic J. Differences in laboratory findings for cerebrospinal fluid specimens obtained from patients with meningitis or encephalitis due to herpes simplex virus (HSV) documented by detection of HSV DNA. Clin Infect Dis 2002; 35:414.
  6. Gomez B, Mintegi S, Rubio MC, et al. Clinical and analytical characteristics and short-term evolution of enteroviral meningitis in young infants presenting with fever without source. Pediatr Emerg Care 2012; 28:518.
  7. de Crom SCM, van Furth MAM, Peeters MF, et al. Characteristics of pediatric patients with enterovirus meningitis and no cerebral fluid pleocytosis. Eur J Pediatr 2012; 171:795.
  8. Sharp J, Harrison CJ, Puckett K, et al. Characteristics of Young Infants in Whom Human Parechovirus, Enterovirus or Neither Were Detected in Cerebrospinal Fluid during Sepsis Evaluations. Pediatr Infect Dis J 2013; 32:213.
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