Version June 2024
| Agents | Effect | Caveats |
| Cyclophosphamide, Ifosfamide | Hemorrhagic cystitis | Uroprotection with mesna, saline and continuous bladder irrigation |
| Busulfan | Hemorrhagic cystitis | Seen with prolonged systemic therapy; long delay of onset |
| Thiotepa | Irritation and rarely hemorrhagic cystitis | Intravesical |
| Doxorubicin | Reversible hemorrhagic cystitis in 20 to 30% | Intravesical |
| Mitomycin | Cystitis in 15% | Intravesical |
| Fludarabine | Rare hemorrhagic cystitis | |
| Chlorambucil | Rare cases of sterile cystitis | |
| Cabazitaxel | Hemorrhagic cystitis in 17%; severe (grade 3 or 4) in 2 to 3% |
|
| Dacarbazine, temozolomide | Rare hemorrhagic cystitis |
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