Estimated percentage of patients (all age groups) that experience adverse effects of benznidazole and nifurtimox

Drug	Side effects	Approximate percentage (range) of patients with adverse effect*
Nifurtimox	Anorexia and weight loss	50 (17 to 70)
	Polyneuropathy^¶	25 (15 to 36)
	Nausea/vomiting	15 (5 to 33)
	Abdominal discomfort	15 (9 to 25)
	Headache	15 (13 to 19)
	Dizziness/vertigo	15 (9 to 25)
	Insomnia	12 (10 to 19)
	Nervous excitation, mood changes	15 (9 to 27)
	Myalgia	12 (11 to 14)
	Disorientation	7 (6 to 10)
	Paresthesia	3 (2 to 3)
	Leukopenia	<3
Benznidazole	Allergic dermatitis^Δ	30 (14 to 50)
	Peripheral neuropathy^¶	30 (0 to 43)
	Anorexia and weight loss	15 (6 to 24)
	Insomnia	5 (0 to 6)
	Nausea and/or vomiting	4 (2 to 6)
	Leukopenia^◊	Rare
	Thrombocytopenia^◊	Rare
	Dysgeusia^§	Rare

* Based on reported frequences from retrospective case series and clinical trials in which standard drug doses were given.
¶ Dose dependent, usually occurs late in course. Reversible but may take months.
Δ Not dose dependent. Discontinue drug if severe. Stevens-Johnson syndrome reported.
◊ Requires discontinuation.
§ Reversible but may take weeks.

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Estimated percentage of patients (all age groups) that experience adverse effects of benznidazole and nifurtimox