European Group for Blood and Marrow Transplantation risk assessment score for allogeneic transplantation in chronic myeloid leukemia

Item	Category	Score
Donor	HLA Identical sibling donor	0
Donor	Matched unrelated donor	1
Stage	First chronic phase	0
	Accelerated phase	1
	Blast crisis or ≥2nd chronic phase	2
Age	<20 years	0
	20 to 40 years	1
	>40 years	2
Sex matching (donor/recipient)	All other matches	0
Sex matching (donor/recipient)	Female donor, male recipient	1
Time to HCT from diagnosis	<12 months	0
Time to HCT from diagnosis	>12 months	1
Score	Treatment-related mortality (%)	5-year Overall Survival (%)
0	20	72
1	23	70
2	31	62
3	46	48
4	51	40
5	71	18
6	73	22
7	-	-

Risk_score_CML_transplantat.htm

Scoring: Scoring is from zero to a maximum of seven, with points scored for each of the five risk categories, as shown in the upper table. Treatment-related mortality and five-year overall survivals as a function of the score are shown in the lower table. There were too few patients with a score of seven to adequately assess TRM and OS.

EGBMT: European Group for Blood and Marrow Transplantation; CML: chronic myelogenous leukemia; HCT: hematopoietic cell transplantation; %: percent.

Data from: Gratwohl, A, et al. Lancet 1998; 352:1087.

Graphic 67260 Version 2.0

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European Group for Blood and Marrow Transplantation risk assessment score for allogeneic transplantation in chronic myeloid leukemia