Classification of systemic reactions to subcutaneous immunotherapy (SCIT)

AAAAI/ACAAI surveillance study

Grade 1 → Mild systemic reactions:

Generalized urticaria and/or upper respiratory symptoms (eg, itching of the palate and throat, sneezing)

Grade 2 → Moderate systemic reactions:

Asthma (eg, PEFR falls 20 to 40%) with or without generalized urticaria, upper respiratory symptoms, or abdominal symptoms (nausea, cramping)

Grade 3 → Severe life-threatening anaphylaxis:

Severe airway compromise due to severe bronchospasm (eg, PEFR falls more than 40%) or upper airway obstruction with stridor, and/or hypotension (with or without loss of consciousness)

AAAAI: American Academy of Allergy, Asthma, and Immunology; ACAAI: American College of Allergy, Asthma, and Immunology; PEFR: peak expiratory flow rate.

Graphic 67718 Version 8.0

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Classification of systemic reactions to subcutaneous immunotherapy (SCIT)