Management of natural killer (NK) cell deficiencies

Intervention	Reported or theoretical benefit	Risks
Antiviral agents	Decrease incidence of disease	Adverse drug reactions Resistance
IVIG	Decrease incidence of disease	Adverse drug reactions Infections/neurodegeneration Inconvenience
IL-2	Increase NK cell function	Adverse drug reactions Autoimmunity
IFN-alfa	Increase NK cell function	Adverse drug reactions Autoimmunity
Stem cell transplantation	Correction of defect	Defect not corrected Transplant-related mortality or morbidity

IVIG: intravenous immune globulin; IL-2: interleukin-2; NK: natural killer; IFN-alfa: interferon-alfa.

Graphic 68545 Version 5.0

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