Staging of acute kidney injury in children: Pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease (pRIFLE) classification

pRIFLE stage	eCCl	Urine output
R = Risk for kidney dysfunction	eCCl decrease by 25%	<0.5 mL/kg per hour for 8 hours
I = Injury to the kidney	eCCl decreased by 50%	<0.5 mL/kg per hour for 16 hours
F = Failure of kidney function	eCCl decreased by 75% or eCCl <35 mL/min per 1.73 m²	<0.3 mL/kg per hour for 24 hours or anuria for 12 hours
L = Loss of kidney function	Persistent failure >4 weeks
E = End-stage kidney disease	Persistent failure >3 months

eCCl: estimated creatinine clearance.

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