Efficacy of weekly infusions of alpha-1 antitrypsin

Serum alpha-1 antitrypsin (AAT) levels by immunodiffusion after once weekly administration of 60 mg/kg of active AAT to patients with the ZZ homozygous form of AAT deficiency. The dashed line represents the protective threshold. Weekly infusions (arrows) maintained the serum A1AT levels above this threshold. Values are in commercial standard units of mg/dL; the true standard levels in µmol/L can be estimated by dividing the immunodiffusion value by 7.3.