Diagnostic criteria for mixed connective tissue disease

Common symptoms

Raynaud's phenomenon

Swollen fingers or hands

Anti U1-RNP antibody

Mixed clinical features

SLE-like findings:

Polyarthritis

Lymphadenopathy

Facial erythema

Pericarditis or pleuritis

Leukopenia or thrombocytopenia

Scleroderma-like findings:

Sclerodactyly

Pulmonary fibrosis, restrictive changes or reduced diffusion capacity

Hypomotility or dilation of the esophagus

Polymyositis-like findings:

Muscle weakness

Elevated serum muscle enzymes

Myogenic pattern on EMG

Diagnosis of MCTD is made when the following three conditions are fulfilled:

1. Positive in either of the two common symptoms

2. Positive anti-U1 RNP antibody

3. Positive in one or more findings in two or three of the above diseases

Diagnostic_criteria_in_MCTD.htm

Adapted from Doria, A, Ghirardello, A, de Zambiasi, P, et al, J Rheumatol 1992; 19:259.

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