Differential diagnosis of morphea*

Scleroderma (systemic sclerosis)

Lipodermatosclerosis

Eosinophilic fasciitis

Trauma-induced

Fat nephrogenic systemic fibrosis necrosis (intramuscular injections)

Chronic graft-versus-host disease

Lichen sclerosus

Pretibial myxedema

Connective tissue nevi

Morpheaform basal cell carcinoma

Chemical mediated sclerosing skin conditions (toxic oil syndrome, rapeseed oil, etc.)

Lyme disease (acrodermatitis atrophicans)

Phenylketonuria

Scleromyxedema, scleroderma chronic, pretibial myxedema

POEMS syndrome

Exclude in pertinent setting

Carcinoma of the breast metastatic to skin (carcinoma en cuirasse)

Porphyria cutanea tarda

POEMS: Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes.
* Arranged in order of likelihood.

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