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Interstitial lung disease

Interstitial lung disease

HRCT: high-resolution computed tomography; ILD: interstitial lung disease; BAL: bronchoalveolar lavage; UIP: usual interstitial pneumonia; IPF: idiopathic pulmonary fibrosis; NSIP: nonspecific interstitial pneumonia; OP: organizing pneumonia; PLCH: pulmonary Langerhans cell histiocytosis; TBB: transbronchial lung biopsy.

* Serology as indicated by clinical findings: rheumatoid factor, anticyclic citrulinated peptide, antinuclear antibody, antisynthetase antibodies, creatine kinase, aldolase, Sjögren antibodies and scleroderma antibodies.

¶ Classic HRCT features of UIP:
  1. Reticular opacities in basal and peripheral distribution.
  2. Traction bronchiectasis.
  3. Honeycombing (clustered airspaces 3 to 10 mm diameter) in subpleural location.
  4. Ground-glass opacities may be present but are less extensive than reticular opacities.
Adapted from: Raghu G. Interstitial lung disease: a diagnostic approach. Are CT scan and lung biopsy indicated in every patient? Am J Respir Crit Care Med 1995; 151:909.
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