Multiple factors probably contribute to the enhanced virulence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)

Virulence determinants include phenol-soluble modulins, alpha-hemolysin, and several of the other determinants shown. The expression of these factors is likely to be under regulatory control. Other factors, such as the host response and factors that facilitate transmission, have yet to be characterized.