Relation between hypertension and development of ESKD

Cumulative incidence of end-stage kidney disease (ESKD), due to any cause, according to blood pressure category in 332,544 males screened for the Multiple Risk Factor Intervention Trial (MRFIT) trial. The adjusted relative risk increased from 1.0 in those with optimal blood pressure (<120/<80) to 1.9 with high-normal blood pressure, 3.1 with mild hypertension, 6.0 with moderate hypertension, and 11.2 with severe hypertension. Patients with stage 1 hypertension or lower blood pressure were at very low risk of ESKD at 16 years (≤0.34%).