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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Characteristics of pancreatic neuroendocrine tumors

Characteristics of pancreatic neuroendocrine tumors
Tumor
(secreted product)		 Clinical presentation Pancreatic localization
(percent)		 Malignancy
(percent)		 MEN1 associated
(percent)		 Incidence in MEN1
(percent)
Insulinoma (insulin) Whipple triad* >97 <10 5 to 10 21
Gastrinoma (gastrin) Zollinger-Ellison syndrome 25 to 60 60 to 90 20 to 30 54
VIPoma (vasoactive intestinal polypeptide) Verner-Morrison syndromeΔ >90 40 to 70 6 17
Glucagonoma (glucagon) Glucagonoma syndrome◊ >95 50 to 80 1 to 20 3
Somatostatinoma (somatostatin) Somatostatinoma syndrome§ 55 >70 45 to 50 <5
MEN1: multiple endocrine neoplasia type 1.
* Hypoglycemic symptoms, low blood glucose levels, reversible upon glucose intake.
¶ Diarrhea, hypergastrinemia, gastric acid hypersecretion, peptic ulcer diathesis.
Δ WDHA syndrome: watery diarrhea, hypokalemia, achlorhydria.
◊ 4D syndrome: necrolytic migrating erythematous dermatitis, diabetes, deep vein thrombosis, depression.
§ (Questionable) elevated somatostatin serum levels, diabetes, hypochlorhydria, cholelithiasis, dia-/steatorrhea, anemia, weight loss.
Data from:
  1. Jensen RT. Pancreatic endocrine tumors: Recent advances. Ann Oncol 1999; 10:170.
  2. Ehehalt F, Saeger HD, Schmidt CM, Grützmann R. Neuroendocrine tumors of the pancreas. Oncologist 2009; 14:456.
Graphic 69622 Version 5.0

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