Toxicities of tamoxifen for patients at high risk of breast cancer in NSABP P-01

Adverse event	Annual rate per 1000 women				RR (95% CI)
	Placebo		Tamoxifen		RR (95% CI)
	≤49 years	≥50 years	≤49 years	≥50 years	≤49 years	≥50 years
Cerebrovascular accident	0.5	1.7	0.57	2.5	1.13 (0.39-3.36)	1.47 (0.97-2.22)
Transient ischemic attack	0.44	1.10	0.25	1.09	0.57 (0.12-2.25)	0.99 (0.56-1.76)
Pulmonary embolism	0.13	0.44	0.25	0.96	2.01 (0.29-22.19)	2.16 (1.02-4.89)
Deep vein thrombosis	0.76	0.89	1.01	1.33	1.34 (0.59-3.10)	1.49 (0.84-2.68)
Invasive endometrial cancer	0.82	0.58	1.16	3.08	1.42 (0.55-3.81)	5.33 (2.47-13.17)

Tamoxifen_toxicities_NSABP.htm

RR: risk ratio for women in the tamoxifen group relative to women in the placebo group; CI: confidence interval.

Data from: Fisher B, et al. J Natl Cancer Inst 2005; 97:1658.

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