Dose dependence of thiazide-induced side effects

Metabolic complications induced by bendrofluazide in relation to daily dose (multiply by 10 to get equivalent doses of hydrochlorothiazide). Increasing the dose led to progressive hypokalemia and hyperuricemia and a greater likelihood of a mild elevation in the FBG, all without a further reduction in the systemic blood pressure. Each treatment group contained approximately 52 patients.