Version May 2024
| Vitamin | Age group | Intake recommendations for cystic fibrosis patients | Monitoring recommendations |
| Vitamin A* | 1 to 12 months | 450 micrograms (1500 units) | Annual measurement of serum retinol[1,2] In the presence of liver disease, serum retinyl-binding protein and retinyl esters should be measured annually in addition to serum retinol[2] |
| 1 to 3 years | 1500 micrograms (5000 units) | ||
| 4 to 8 years | 1500 to 3000 micrograms (5000 to 10,000 units) | ||
| >8 years | 3000 micrograms (10,000 units) | ||
| Adult | 3000 micrograms (10,000 units) | ||
| Vitamin E¶ | 1 to 12 months | 40 to 50 mg | Annual measurement of serum alpha-tocopherol[1] |
| 1 to 3 years | 80 to 150 mg | ||
| 4 to 8 years | 100 to 200 mg | ||
| 9 to 18 years | 200 to 400 mg | ||
| Adult | 200 to 400 mg[2] | ||
| Vitamin K | 1 to 12 months | 0.3 to 0.5 mg | Annual measurement of serum prothrombin time and PIVKA II Additional supplementation may be required during antibiotic therapy If found to be deficient, repeat measurement 1 to 2 months following therapy to confirm normalization |
| 1 to 3 years | 0.3 to 0.5 mg | ||
| 4 to 8 years | 0.3 to 0.5 mg | ||
| 9 to 18 years | 0.3 to 0.5 mg | ||
| Adult | 2.5 to 5 mg/week |
PIVKA: protein induced by vitamin K absence.
* Vitamin A doses given as retinol activity equivalents (RAEs). 1 RAE = 3.33 units = 1 microgram retinol = 12 microgram beta-carotene.
¶ Vitamin E is measured as alpha-tocopherol; 1 mg alpha-tocopherol = 1.47 units "natural-source" vitamin E (RRR-alpha-tocopherol), or 2.2 units synthetic vitamin E ("all-racemic" vitamin E).Modified with permission from: Maqbool A, Stallings VA. Update on fat-soluble vitamins in cystic fibrosis. Curr Opin Pulm Med 2008; 14:574. Copyright © 2008 Lippincott Williams & Wilkins.
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