Differential diagnosis of pediatric multiple sclerosis

Inflammatory disease	ADEM/MDEM, MOGAD, NMOSD, SLE, PACNS, APS, Sjögren's disease, Behçet syndrome
CNS malignancy	Lymphoma, high grade glioma, hemophagocytic lymphohistiocytosis
Leukodystrophy	Metachromatic leukodystrophy, X-linked adrenoleukodystrophy, Alexander disease
CNS infection	Acute bacterial or viral infections, Lyme disease, West Nile virus, syphilis, HIV
Vitamin deficiency	B12, folate
Granulomatous disease	Neurosarcoidosis, granulomatosis with polyangiitis (Wegener)
Mitochondrial disease	Leber hereditary optic neuropathy

ADEM: acute disseminated encephalomyelitis; APS: antiphospholipid syndrome; CNS: central nervous system; HIV: human immunodeficiency virus; MDEM: multiphasic disseminated encephalomyelitis; MOGAD: myelin oligodendrocyte glycoprotein antibody-associated disease; NMOSD: neuromyelitis optica spectrum disorders; PACNS: primary angiitis of the central nervous system; SLE: systemic lupus erythematosus.

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خرید پکیج

Differential diagnosis of pediatric multiple sclerosis