Allogeneic hepatocyte transplantation for patients with chronic liver failure

Diagnosis, [reference]	Age	Outcome
Cryptogenic cirrhosis
[1]	3 weeks	Intraportal (7x10⁸ cells). NH₃ ↓. OLT after 1 week with full recovery.
TPN + sepsis (Child C)
[2]	6 months	Splenic artery infusion (5x10⁷ cells). NH₃ ↓; encephalopathy improved. Intracranial hemorrhage on d7.
Alpha-1 antitrypsin disease (PiZZ), cirrhosis; pulmonary insufficiency, encephalopathy grade 4; Child C
[2]	52 years	NH₃ ↓, PiMM alpha-1 present in plasma. OLT on d2 with full recovery.
HCV, cirrhosis, Child C encephalopathy grade 4
[2]	40 years	Intracranial hemorrhage on d2 (hepatocytes in spleen at autopsy).
EtoH cirrhosis. Male, Child C; encephalopathy grade 3
[3]	62 years	Splenic artery infusion (6x10⁸). Encephalopathy improved, and NH₃ ↓, full recovery. Hyperkalemic cardiac arrest at day 33.
EtoH cirrhosis. Male, encephalopathy grade 3
[4]	46 years	No improvement, death on day 50.

Chronic_liver_failure.htm

1. Soriano HE, Wood RP, Kang DC, et al. Hepatocellular transplantation HCT) in children with fulminant liver failure. Hepatology 1997; 30:239A.
2. Strom SC, Fisher RA, Thompson MT, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63:559.
3. Sterling RK, Fisher RA. Liver Transplantation: Living Donor, Hepatocyte, and Xenotransplantation. In: Current Future Treatment Therapies for Liver Disease. Clinics in Liver Disease. Gish, R, ed. Philadelphia: WB Saunders, 2001.
4. Strom SC, Roy-Chowdhury J, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 1999; 19:39.

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Allogeneic hepatocyte transplantation for patients with chronic liver failure