Version June 2024
| Signs and symptoms | Percent at onset | Percent at any time |
| Fatigue | 50 | 74 to 100 |
| Fever | 36 | 40 to 80+ |
| Weight loss | 21 | 44 to 60+ |
| Arthritis or arthralgia | 62 to 67 | 83 to 95 |
| Skin | 73 | 80 to 91 |
| Butterfly rash | 28 to 38 | 48 to 54 |
| Photosensitivity | 29 | 41 to 60 |
| Mucous membrane lesion | 10 to 21 | 27 to 52 |
| Alopecia | 32 | 18 to 71 |
| Raynaud phenomenon | 17 to 33 | 22 to 71 |
| Purpura | 10 | 15 to 34 |
| Urticaria | 1 | 4 to 8 |
| Renal | 16 to 38 | 34 to 73 |
| Nephrosis | 5 | 11 to 18 |
| Gastrointestinal | 18 | 38 to 44 |
| Pulmonary | 2 to 12 | 24 to 98 |
| Pleurisy | 17 | 30 to 45 |
| Effusion | 24 | |
| Pneumonia | 29 | |
| Cardiac | 15 | 20 to 46 |
| Pericarditis | 8 | 8 to 48 |
| Murmurs | 23 | |
| ECG changes | 34 to 70 | |
| Lymphadenopathy | 7 to 16 | 21 to 50 |
| Splenomegaly | 5 | 9 to 20 |
| Hepatomegaly | 2 | 7 to 25 |
| Central nervous system | 12 to 21 | 25 to 75 |
| Functional | Most | |
| Psychosis | 1 | 5 to 52 |
| Convulsions | 0.5 | 2 to 20 |
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