Urinary molecular markers for the detection of bladder cancer

Target	Sensitivity (%)	Specificity (%)	False positive in
Bladder tumor antigen	50 to 90	90	Urinary tract infection, hematuria, calculi, BPH, prior intravesical treatment
NMP 22	42 to 100	70 to 91	Inflammation
NMP 52	97	94
BLCA-4	89 to 96	95 to 100
BLCA-1	80	87
Survivin	64 to 100	93 to 100
CK 8 and CK 18	35 to 79	68
CK 19	43 to 96	70	Urinary tract infection, calculi, post-BCG
FDP	70	68 to 86
Hyaluronic acid, hyaluronidase	82 to 100	81 to 90
mRNA markers
Cxbladder*	74 to 95	45 to 81
Xpert Bladder Cancer Monitor^¶	46 to 84	77 to 95
Bladder EpiCheck	62 to 68	82 to 88

BPH: benign prostatic hyperplasia; NMP: nuclear matrix protein; BLCA-4: bladder cancer-associated NMP 4; CK: cytokeratin; BCG: Bacillus Calmette-Guerin; FDP: fibrin degradation products.

* Cxbladder test: IGFBP5, HOXA13, MDK, CDK1, CXCR2.

¶ Xpert Bladder Cancer Monitor test: IGF2, ANXA10, ABL1, UPK1B, CRH.

Graphic 70530 Version 6.0

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Urinary molecular markers for the detection of bladder cancer