Version June 2024
| Clinical features | Subcutaneous fat necrosis of the newborn | Sclerema neonatorum |
| Onset | 0 to 4 weeks of age | 0 to 7 days of age |
| Gestational age | Usually term | Usually preterm |
| Associated conditions | Birth trauma, including asphyxia, mechanical trauma, thermal trauma | Serious underlying disease, including congenital malformations, sepsis, respiratory and gastrointestinal disease |
| Site and spread | Bony prominences; remains localized | Begins on trunk or lower limb and may become generalized; spares palms and soles |
| Morphology | Circumscribed subcutaneous plaques or nodules | Hard, wax-like skin and subcutaneous tissue; does not pit |
| Mobility | Move freely over muscles and bone | Bound to underlying muscle and bone |
| Histopathology | Fat necrosis; extensive granulomatous inflammatory infiltrate; needle-shaped clefts within adipocytes | Thickened fibrous septae; sparse nongranulomatous inflammatory infiltrate; needle-shaped clefts within adipocytes |
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