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Effects of GnRH agonist alone (solid lines) versus GnRH agonist plus low-dose estrogen-progestin add-back (dotted line) on bone mineral density at the end of 6 months of treatment and then after 6 months of follow up

Effects of GnRH agonist alone (solid lines) versus GnRH agonist plus low-dose estrogen-progestin add-back (dotted line) on bone mineral density at the end of 6 months of treatment and then after 6 months of follow up
Note that the low-dose estrogen plus progestin add-back was associated with continuing bone loss during treatment, but the bone loss was less than that observed in the group treated with the GnRH agonist alone.
Reproduced with permission from: Howell R, Edmonds D, Dowsett M. Gonadotropin releasing hormone analogue plus hormone replacement therapy for the treatment of endometriosis: a randomized clinical trial. Fertil Steril 1995; 64:474. Copyright © 1995 American Society for Reproductive Medicine.
Graphic 70640 Version 2.0

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