Histologic improvement and change in Ishak Fibrosis Score at week 48, nucleoside-naive patients

	(HBeAg-positive)		(HBeAg-negative)
	Entecavir 0.5 mg (n = 314)*	Lamivudine 100 mg (n = 314)*	Entecavir 0.5 mg (n = 296)*	Lamivudine 100 mg (n = 287)*
Histologic improvement (Knodell scores)
Improvement^¶	72%^Δ	62%	70%^Δ	61%
No improvement	21%	24%	19%	26%
Ishak Fibrosis Score
Improvement^◊	39%	35%	36%	38%
No change	46%	40%	41%	34%
Worsening^◊	8%	10%	12%	15%
Missing week 48 biopsy	7%	14%	10%	13%

* Patients with evaluable baseline histology (baseline Knodell Necroinflammatory Score ≥2).
¶ ≥2-point decrease in Knodell Necroinflammatory Score from baseline with no worsening of the Knodell Fibrosis Score.
Δ p<0.05.
◊ For Ishak Fibrosis Score, improvement = ≥1-point decrease from baseline and worsening = ≥1-point increase from baseline.

Graphic 70763 Version 4.0

خرید پکیج

Histologic improvement and change in Ishak Fibrosis Score at week 48, nucleoside-naive patients